Johns Hopkins Medical Institutions

Program Co-Director	Program Co-Director
Mark A. Marzinke, PhD, DABCC	William Clarke, PhD, MBA, DABCC
Director, General Chemistry	Director, Clinical Toxicology and POCT | Vice-Chair for Quality and Regulatory Affairs
Mmarzin1@jhmi.edu	wclarke@jhmi.edu
(443) 287-7516	(410) 502-7692

About the Program

The Department of Pathology offers a one- or two-year fellowship to provide MD pathologists and PhD scientists with the analytical, clinical, research, and management experience towards specialization and board certification in clinical chemistry. The Clinical Chemistry Division performs over seven million tests each year in state-of-the-art laboratories that provide 24-hour service to The Johns Hopkins Hospital, the Bayview Medical Center, and several community outpatient facilities. The fellow rotates through routine automated chemistry (high-volume testing), critical care (blood gases, stat testing), special chemistry (immunoassay for endocrine function and tumor markers, trace metal analysis) and drug analysis (therapeutic drug monitoring and drugs of abuse testing) laboratories.

The program is designed to provide training in the operation of a clinical laboratory, quality control and assurance, laboratory management, analytical methodologies and test interferences. The clinical interpretation and diagnostic relevance of tests are emphasized through clinical consults. Research projects could involve method development, test validation, and clinical and scientific investigation in any of the areas within clinical chemistry. In addition, there are opportunities to conduct translational research in the field of clinical proteomics through the Center for Biomarker Discovery at Johns Hopkins University. The structure of the program is flexible to afford individualized training based on previous experience.

Program Requirements

To be considered for the program, prospective fellows must have:

1. MD or PhD (or an equivalent doctoral degree) in the basic sciences; chemistry, biology or physics from an accredited university or college.
2. Successfully completed enough chemistry courses to apply to the American Board of Clinical Chemistry, i.e., a minimum of 30 semester hours (or equivalent) in undergraduate and/or graduate level chemistry or biochemistry courses taken at institutions acceptable to the Board.

To Apply

Deadline for applications is September 1, for fellows applying for a start date of July the following year. Formal interviews begin no earlier than September 1 (short informal discussions e.g. via phone or at ADLM meeting may be conducted prior to September 1). Offers will be extended to the selected candidate no earlier than October 1. Candidates will be given a window of at least 2 weeks from the time of notification to consider the offer.

The application packet must include:

1. Letter of intent & Curriculum vitae (submitted to the program co-directors for initial consideration)
2. Selected applicants will be required to complete a formal application
   • Transcripts (undergraduate and graduate)
   • Three letter of recommendation

Initial screening will be performed via virtual interviews, with 2-3 select candidates invited for an on-site interview to include meetings with selected faculty, tours of clinical and research laboratories, and a research talk by the candidate.

(Johns Hopkins does not discriminate on the basis of race, color, sex, religion, homosexuality, nation or ethnic origin, age, disability, or veteran status in any student program or activity administered by the University or with regard to admission or employment.).

Training Level

Postdoctoral Training Level
Number of positions available per year: 1 per year
Duration of program: 2 years
Approximate annual salary or stipend: PGY Scale
Source of funding: Department Funding, Endowment, NIH Grants, Industry Contracts
Current number of trainees: 2
Number of past graduates: 26

Faculty

Daniel W. Chan, PhD, DABCC	Cancer Proteomics, Tumor Markers, Immunoassay Automation
William Clarke, PhD, DABCC	Therapeutic Drug Monitoring, Clinical Toxicology, Mass Spectrometry Assay Development
Mark Marzinke, PhD, DABCC	Pharmacogenetics, Lab Automation, Mass Spectrometry, Pharmacology, Quality Improvement
Lori J. Sokoll, PhD	Tumor Markers, Immunoassays
Hui Zhang, PhD	Clinical Proteomics, Glycoproteomics, Mass Spectrometry
Zhen Zhang, PhD	Bioinformatics, Mathematical and Computational algorithms
Patrizio Caturegli, MD, MPH	Immunology
Ivo Francischetti, MD, PhD	Hematology and Coagulation
Rena Xian, MD, MS	Molecular Pathology