Cleveland State University/Cleveland Clinic

Cleveland State University/Cleveland Clinic

Director

David Anderson, PhD, DABCC
Department of Chemistry
Cleveland State University
2121 Euclid Avenue
Cleveland, OH 44115
Telephone: 216-687-2453
Fax: 216-687-9298
E-mail: d.anderson@csuohio.edu

Faculty and Research Interests

Cleveland Clinic – Department of Chemistry
David Anderson, PhD, DABCC HPLC and mass spectrometry of proteins, proteomics, pharmacokinetic studies, gangliososides in glaucoma
David Ball, PhD Matrix isolation; vibrational spectroscopy; computational chemistry; high energy materials; chemical education
Mekki Bayachou, PhD Functional biomaterials, antithrombotic surfaces, electron-transfer; nitric oxide synthases; metalloproteins; metalloenzymes; cyt P450s; bio-electrochemistry; DNA-sensors; DNA-protein interaction; small molecule metabolite sensors; nanotechnology
Anthony Berdis, PhD DNA replication, chemotherapy, mutagenesis, cancer biology, nucleoside analogs, pharmacology, drug discovery, medicinal chemistry
Warren Christopher Boyd, PhD Transition metals, coordination chemistry, organometallic chemistry, iron, cobalt, ruthenium, nitric oxide, nitrosoalkanes, azodioxides, nitrosamines, catalysis, redox-active ligands, photochemistry
Valentin Gogonea, PhD Computational chemistry, enzyme reactivity, nitric oxide synthase, hydrogenase, cholesterol transport, deuterium exchange, quantum mechanical molecular mechanics, molecular dynamics, protein folding
Baochuan Guo, PhD MALDI-TOF based DNA sequencing, mass spectrometric immunoassay, mass spectrometry characterization of synthetic polymers
Michael Kalafatis, PhD Thrombosis, haemostasis, coagulation factors, factor V, factor X, prothrombin, prothrombinase, thrombin, platelets, endothelial cells, kinase, phosphorylation, signal transduction, cancer, cell division, apoptosis, kinase, lupus anticoagulant
John Masnovi, PhD Electron transfer chemistry, organic, bio-organic, organometallic chemistry
Yana Sandlers, PhD Clinical mass spectrometry, newborn screening, metabolic disorders, metabolomics
Bin Su, PhD Drug development, cancer, African trypanosomiasis, synthetic medicinal chemistry, pharmacology
Xue-Long Sun, PhD Antithrombtic and antiviral drugs, drug delivery, glycan microarray, biosensor, glycomics, cellular chemistry, chemical biology, biopharmaceutical chemistry
John Turner, II, PhD Raman spectroscopy, fluorescence, infrared, IR, near infrared, NIR, visible, chemical imaging, multivariate analysis, chemometrics, mineral, biomineral, bone, teeth, biomaterials, implant materials
Yan Xu, PhD Mass spectrometry, liquid chromatography, capillary electrophoresis, electrochemical enzyme immunoassay, fluorometry, analytical method development and validation, drug metabolism and pharmacokinetics, DNA base excision repair pathways, drug discovery program
Aimin Zhou, PhD RNAse L biochemistry in infectious diseases, cancer, cardiovascular disease, diabetes, inflammatory conditions, apoptosis and cell signaling. disease marker discovery.
Cleveland Clinic – Department of Clinical Pathology
Sihe Wang, PhD, DABCC Chromatography and mass spectrometry for specialty testing, general clinical chemistry, new biomarkers for cardiovascular or kidney diseases
Manjula Gupta, PhD Immunology, cancer, endocrinology
Cleveland Clinic – Lerner Research Institute
Alex Almasan, PhD Autophagy; apoptosis; cell cycle; DNA damage; DNA repair; cancer therapeutics; radiation therapy; leukemia; epithelial tumors; prostate cancer
Suneel Apte M.B.B.S ,PhD Extracellular matrix; metalloproteinases; ADAMTS proteins; morphogenesis; birth defects; eye disorders; cardiovascular biology; smooth muscle; musculoskeletal biology; post-translational modification; inherited connective tissue disorders
Mark Aronica MD Extracellular matrix, airway inflammation, asthma
Tatiana Byzova, PhD Angiogenesis; endothelial cells; integrins; extracellular matrix; cell adhesion; tumor progression; vascular biology; signal transduction in endothelium and platelets; oxidative stress and vasculature; toll-like receptors in angiogenesis.
Kathleen Berkner, PhD Vitamin K; vitamin K-dependent protein carboxylation; hemostasis; anticoagulation; calcification; vitamin K-dependent clotting factors deficiency (VKCFD); pseudoxanthoma elasticum; warfarin resistance; gamma-glutamyl carboxylase; vitamin K oxidoreductase (VKOR)
John Crabb, PhD Mass spectrometry in proteomics, age-related macular degeneration, glaucoma
Carol de la Motte, PhD Hyaluronan-mediated platelet-endothelial interactions in inflammation; role of hyaluronan in angiogenesis associated with inflammatory bowel disease; hyaluronan mediated recruitment of endothelial progenitor cells in lung repair
Donna Driscoll, PhD RNA biology; mRNA translational control; nutritional regulation of gene expression; selenium
Serpil Erzurum, MD Airway inflammation and host defense, reactive oxygen and nitrogen species in lung disease, pulmonary vascular endothelium and angiogenesis, asthma, pulmonary hypertension
Paul Fox, PhD Angiogenesis; atherosclerosis; cell migration; endothelial cells; iron metabolism; macrophages; translational control
Stanley Hazen, MD, PhD Inflammation; atherosclerosis; asthma; myeloperoxidase; cardiovascular diseases; HDL; peroxidases; airway remodeling; intestinal microbiota; gut flora; cardiometabolic disease
Sadashiva Karnik, PhD GPCRs; angiotensin receptors; ARBs; biased signaling; cardiac hypertrophy; hypertension; heart failure; structure-function of GPCRs; transmembrane signaling; microRNA; gene expression; chromatin protein modifications; STAT3 and U-STAT3 signaling; RGS proteins.
Xiaoxia Li, PhD Signal transduction in innate and adaptive immunity
Thomas McIntyre, PhD Lipid mediators; inflammatory signaling; platelet biology; biochemistry; acute kidney injury
Richard Padgett, PhD Transcription; RNA processing; RNA splicing; splicing factors; relation to cancer and developmental diseases; gene structure and function; genomics; evolution of genomes; RNA biochemistry
Edward Plow, PhD Integrins; plasminogen; kindlins; thrombospondins; atherothrombosis.
Eugene Podrez, MD, PhD Atherosclerosis; thrombosis; atherothrombosis; platelets; macrophage; scavenger receptors; ldl; hdl; cholesterol; phospholipids; oxidative stress; lipid peroxidation.
Jun Qin, PhD Signal transduction; integrin; cell adhesion; cell migration; kinase; heart disease; cancer; structural biology; protein NMR; protein crystallography
Nima Sharifi, MD Prostate cancer; androgens; metabolism; steroids; castration-resistant prostate cancer; androgen receptor; hormone therapy; medical oncology; dihydrotestosterone; enzymes; biochemistry
Robert Silverman, PhD Interferon; rnase l; antiviral innate immunity; prostate cancer; oncolytic virotherapy
Jonathan Smith, PhD Atherosclerosis; HDL metabolism; atrial fibrillation; genetics; genomics; eQTL; gene expression; reverse cholesterol transport; dysfunctional HDL; RNAseq; allelic expression imbalance; ABCA1; mouse models; zinc finger nuclease
George Stark, PhD Interferons; IL-6; NFkB; STAT3; EGFR; drug resistance; DNA repair; lung cancer; breast cancer; prostate cancer; glioblastoma; septic shock
Dennis Stuehr, PhD Structure and biochemistry of nitric oxide synthases and related enzymes
Wilson Tang MD Role of nitrative stress and counter-regulatory mechanisms in the development and progression of heart failure, integrative genomics and metabolomics in cardiomyopathy, cardio-renal physiology, and device-based treatment and remote monitoring in heart failure disease management
Bruce Trapp, PhD Multiple sclerosis; glia; oligodendrocytes; astrocytes; neuroprotection; myelin
Qing Wang, PhD Genetics and genomics; Genome-Wide Association Studies (GWAS); next generation sequencing; genome editing; iPSCs of human disease; mouse and zebrafish models of human disease; physiology; development; signal transduction; targeted therapy.
Qingyu Wu, MD, PhD Blood pressure; cardiac function; cardiovascular disease; cell membrane proteases; corin; hormone processing; hypertension; preeclampsia; pregnancy-induced hypertension; proteolytic enzymes; vascular biology.
Qing Yi MD, PhD Antitumor immune response; C-reactive protein; cancer; drug resistance; idiotype; immunotherapy; mantle cell lymphoma; monoclonal antibodies; multiple myeloma; T cells; tumor microenvironment; vaccines
Bin Zhang, PhD Mechanism of intracellular trafficking in human disease development; protein secretion; endoplasmic reticulum stress; cargo receptors; cardiovascular diseases; cancer
Case Western Reserve University
Romani Andrea MD, PhD Regulation of magnesium homeostasis and transport in mammalian cells

Program Listing

Level(s) of training: PhD
Number of positions available per year: varies
Duration of program: 4-6 years
Approximate annual salary or stipend: $21,000 (pre-candidacy assistantship) $22,500 (post-candidacy assistantship) Assistantship also provides full annual tuition fees (approximately $9600 – $14,000)
Source of funding: $21,000 (pre-candidacy assistantship) $22,500 (post-candidacy assistantship) Assistantship also provides full annual tuition fees (approximately $9600 – $14,000)
Current number of trainees: 20
Number of past graduates (over last 10 years): 27

Application Procedures

Prerequisites

Minimum requirements for admission are bachelor’s degree in a basic science, laboratory medical science or related field, with a minimum grade point average (GPA) of 3.00. The requirement for obtaining and maintaining a teaching assistantship is a GPA ≥ 3.25, while the requirement for obtaining and maintaining a research assistantship funded by a grant is a GPA ≥ 3.00. Assistantships under normal circumstances are provided for up to 6 years of study in the program, contingent on above GPA requirements, as well as acceptable performance of duties. One year of general, organic, analytical, and physical chemistry; a year of physics; and mathematics through partial derivatives and multiple integrals is required. Applicants lacking any of these course requirements may be admitted, but any deficiency must be made up as soon as possible.

Procedures

Apply to the doctoral program in Clinical Bioanalytical Chemistry (in which the doctoral Clinical Chemistry program resides). Instructions, procedures and how to submit the application are given at: http://www.csuohio.edu/graduate-admissions/how-apply

Materials required for application are official transcripts from undergraduate and graduate institutions attended and two letters of reference. TOEFL test scores are required for international applicants. International applicants are also required to submit graduate record examination (GRE) scores (verbal and quantitative).

Deadline

January 15 for fall semester of the same year and September 15 for spring semester of the following year.

Program Description

The ComACC-accredited doctoral program in Clinical Chemistry is a dynamically integrated program merging the fields of biomedicine, clinical diagnosis, and analytical chemistry. The mission of the CSU-CC doctoral program in Clinical Chemistry is to give Ph.D. graduate students intensive didactic instruction in the field of clinical laboratory science, as well as some limited experience in the clinical laboratory, and finally to give significant biomedical research experience in dissertation work, in order to prepare students for one of the following paths upon graduation:

  1. to obtain further practical training in the field through clinical chemistry post-doctoral fellowships, in order to prepare them for careers as directors of clinical laboratories;
  2. to directly assume other scientific positions in clinical laboratories, either at medical institutions or reference laboratories;
  3. to assume positions in the in-vitro diagnostics, pharmaceutical or biotechnology industries, which are increasingly seeking scientists with knowledge of clinical chemistry.

The program sets high standards of excellence in delivering its curriculum to prepare students for these careers. Knowledge of both clinical aspects and interpretation of test results, as well knowledge of analytical techniques and various aspects of the quality operation in the clinical laboratory, are central to the program’s goals and mission. Additionally the program mentors students to become independent researchers, educating and mentoring the student in cutting-edge analytical methodologies and novel clinical/biomedical research, such that the Ph.D. recipient can make significant scientific contributions to the field of clinical chemistry. A particular analytical strength of the program is the dissertation research utilizing mass spectrometry instrumentation at CSU and the Cleveland Clinic. Finally the program involves students in the activities of the NEOhio American Association for Clinical Chemistry, fostering their professional development.

The doctoral degree program in Clinical Bioanalytical Chemistry, in which the ComACC-accredited program is a specialized tract, is a joint program of Cleveland State University and the Cleveland Clinic. The ComACC-accredited program is also affiliated with Saint Vincent Charity Medical Center and University Hospitals Case Medical Center in Cleveland. The Clinical Chemistry program gives rigorous instruction in all aspects of disease processes, with in-depth coverage given for testing strategies and methodologies used in disease diagnosis. The instructional and training components are carried out by clinical chemistry faculty in the Department of Chemistry at Cleveland State University, with active participation of the clinical scientists at Cleveland area medical institutions and reference laboratories.

Doctoral clinical chemistry students take one year of Clinical Chemistry (two 4-credit courses); one year of Advanced Biochemistry (two 4-credit courses); a course in Biotechnology Techniques (4 credits), which is a laboratory course in traditional biomedical research techniques, or alternatively, a course in Pharmaceutical Analysis Laboratory (4 semester credits), which is a laboratory course in advanced analytical instrumentation techniques; a course in Clinical Laboratory Topics: Instrumentation and Quality Operation (3-4 credits), four Special Topics in Clinical Chemistry courses, covering various topics in clinical laboratory science ( 1 credit each), several Clinical Chemistry Seminar courses (1 semester credit each) and an Internship in Clinical Chemistry (3 credits) course, involving rotation in a medical center clinical laboratory, where the student learns the principles and practice of clinical laboratory testing. Students may also have the opportunity to work on developmental projects in clinical laboratory.

Dissertation research is an important component of the Clinical Chemistry PhD program. PhD students begin earnest work on their dissertation research at the start of their second year. Students do research at state-of-the-art facilities at Cleveland State University and the Cleveland Clinic. The program includes 47 faculty members who collectively have a broad range of research interests in the fields of disease mechanisms and diagnosis, bioanalytical chemistry, biomedicine, and molecular biology. CSU chemistry faculty undertake biomedical research in areas pertinent to clinical chemistry, including: mass spectrometry, HPLC, biomedical imaging, biosensors, nanotechnology, computational chemistry, coagulation biochemistry, protein chemistry, microarrays, molecular biology, cancer biochemistry, metabolomics, proteomics and pharmacokinetics. Program faculty at the Lerner Research Institute at Cleveland Clinic undertakes basic biomedical research in the areas of molecular biology, cellular and molecular medicine, cancer biology, neurosciences, molecular cardiology, immunology, pathobiology, genomic medicine, stem cell biology and regenerative medicine, ophthalmic research and biomedical engineering.