Director
David Anderson, PhD, DABCC
Department of Chemistry
Cleveland State University
2121 Euclid Avenue
Cleveland, OH 44115
Telephone: 216-687-2453
Fax: 216-687-9298
E-mail: d.anderson@csuohio.edu
Affiliated Institutions
Children’s Hospital Medical Center of Akron
MetroHealth Medical Center
Saint Vincent Charity Medical Center
University Hospitals Case Medical Center
Faculty and Research Interests
| Cleveland State University: | Department of Chemistry |
| David Anderson, PhD, DABCC | HPLC and mass spectrometry – proteins, proteomics, pharmacokinetic studies, gangliosides in glaucoma; HPLC development and innovation |
| David Ball, PhD | Vibrational spectroscopy; computational chemistry; high energy materials; chemical education |
| Mekki Bayachou, PhD | Functional biomaterials; antithrombotic surfaces; electron-transfer; nitric oxide synthases; metalloproteins; metalloenzymes; cyt P450s; bio-electrochemistry; DNA-sensors; DNA-protein interaction; small molecule metabolite sensors; nanotechnology |
| Anthony Berdis, PhD | DNA replication; chemotherapy; mutagenesis; cancer biology; nucleoside analogs; pharmacology; drug discovery; medicinal chemistry |
| Warren Christopher Boyd, PhD | Transition metals; coordination chemistry; organometallic chemistry; iron; cobalt; ruthenium; nitric oxide; nitrosoalkanes; azodioxides; nitrosamines; catalysis; redox-active ligands; photochemistry |
| Valentin Gogonea, PhD | Computational chemistry; enzyme reactivity; nitric oxide synthase; hydrogenase; cholesterol transport; deuterium exchange; quantum mechanical molecular mechanics; molecular dynamics; protein folding |
| Baochuan Guo, PhD | MALDI-TOF based DNA sequencing; mass spectrometric immunoassay; mass spectrometry characterization of synthetic polymers |
| Sameh Hemley | Organic photochromism; monolithic supported radical catalysts |
| Michael Kalafatis, PhD | Thrombosis; haemostasis; coagulation factors; factor V; factor X; prothrombin; prothrombinase; thrombin; platelets; endothelial cells; kinase; phosphorylation; signal transduction; cancer; cell division; apoptosis; kinase; lupus anticoagulant |
| Yana Sandlers, PhD | Clinical chemistry; mass spectrometry; inborn errors of metabolism;metabolomics; induced stem cells derived cardiomyocytes (iPSCM); Barth syndrome; cardiomyopathy |
| Bin Su, PhD | Drug development; cancer; african trypanosomiasis; synthetic medicinal chemistry |
| Xue-Long Sun, PhD | Pharmaceutical chemistry; chemical biology; biopharmaceutical chemistry; cellular chemistry; glyco-engineering; antithrombtic and antiviral drugs; immunomodulation |
| John Turner, II, PhD | Raman spectroscopy; fluorescence; infrared; IR; near infrared; NIR; visible; chemical imaging; multivariate analysis; chemometrics; mineral; biomineral; bone; teeth; biomaterials; implant materials; bioanalysis; spectral imaging; hyperspectral imaging; multispectral imaging; liquid crystal tunable filter; LCTF; acousto-optic tunable filter; AOTF; CCD; charge coupled device, spectroscopy; gemology; gemstone; mineralogy; geology; Raman database; poly-l-lactide |
| Yan Xu, PhD | Clinical and preclinical pharmacokinetics; analytical method development for drugs and metabolites; lipidomic profiling and quantitation of biomarkers of human diseases; metabolic flux analysis of biochemical pathways; metabolomics of multicomponent formulations; mass spectrometry; liquid and gas chromatography; enzyme immunoassay; capillary electrophoresis; electroanalytical techniques |
| Aimin Zhou, PhD | Interferon; RNase L; inflammatory diseases; gene expression |
| Cleveland Clinic: | Robert J. Tomsich Pathology and Laboratory Medicine Institute |
| Edmund Z. Reineks, MD/PhD, DABCC | Point of care testing; quality; lab directorship; special topics |
| Adam McShane, PhD, DABCC | Automated chemistry; cardiovascular disease; blood gases |
| Marvin Natowicz, MD/PhD | Biochemical genetics; metabolic diseases |
| Xiaochun (Susan) Zhang, MD/PhD, DABCC, DABMLI | Immunology; CRO |
| Tom Daly, MD | Laboratory operations and finance |
| Manjula Gupta, PhD | Cancer; endocrinology |
| Jessica Colon-Franco, PhD, DABCC | Endocrinology; special chemistry; leadership |
| Kamran Kadkhoda, PhD, DABMLI | Immunopathology; serology; allergy; cellular immunology |
| MetroHealth Medical Center: | Pathology Department |
| Michael Ip, PhD, DABCC | Clinical chemistry; endocrinology; prenatal diagnosis; infertility; POCT; clinical toxicology; critical care lab; rapid response labs |
| Akron Children’s Hospital: | Department of Pathology and Laboratory Medicine |
| Sihe Wang, PhD, DABCC | General clinical chemistry; pediatric testing; chromatography; mass spectrometry; assay development; CLIA regulation; laboratory management; process improvement |
| Quest Diagnostics Cleveland | HeartLab Center of Excellence |
| Deborah Sun, PhD | Clinical laboratory operations and management |
| Cleveland Clinic: | Lerner Research Institute/Other |
| Ashok Agarwal, PhD | Biological markers of oxidative stress; proteomic and bioinformatics in DNA damage, apoptosis and preserving fertility in patients with cancer; laboratory and clinical studies assessing efficacy of certain antioxidants in improving male fertility |
| Alex Almasan, PhD | Autophagy; apoptosis; cell cycle; DNA damage; ubiquitin; DNA repair; cancer therapeutics; radiation therapy; leukemia; epithelial tumors; prostate cancer |
| Suneel Apte M.B.B.S, PhD | Extracellular matrix; proteolysis; metalloproteinases; ADAMTS proteases; ADAMTS-like proteins; proteomics; morphogenesis; cardiovascular; musculoskeletal; birth defects; fetal-maternal medicine; eye disorders; neural tube; craniofacial development; smooth muscle; post-translational modification; inherited connective tissue disorders; osteoarthritis; primary cilium |
| Mark Aronica MD | Mechanisms by which specific ECM proteins contribute to the onset of asthma |
| Mark Brown, PhD | Lipid metabolism; lipoprotein metabolism; atherosclerosis; obesity; diabetes; reverse cholesterol transport; triacylglycerol; nutrition |
| Tatiana Byzova, PhD | Angiogenesis; endothelial cells; integrins; extracellular matrix; cell adhesion; tumor progression; vascular biology; signal transduction in endothelium and platelets; oxidative stress and vasculature; toll-like receptors in angiogenesis. |
| Kathleen Berkner, PhD | Vitamin K; vitamin K-dependent protein carboxylation; hemostasis; anticoagulation; calcification; vitamin K-dependent clotting factors deficiency (VKCFD); pseudoxanthoma elasticum; warfarin resistance; gamma-glutamyl carboxylase; vitamin K oxidoreductase (VKOR) |
| John Crabb, PhD | Eye; age-related macular degeneration; glaucoma; uveal melanoma; proteomics |
| Donna Driscoll, PhD | RNA biology; mRNA translational control; nutritional regulation of gene expression; selenium |
| Serpil Erzurum, MD | Asthma; pulmonary vascular disease; hypoxia; metabolism |
| Paul Fox, PhD | Angiogenesis; atherosclerosis; cell migration; endothelial cells; iron metabolism; macrophages; translational control |
| Stanley Hazen, MD, PhD | Inflammation; atherosclerosis; asthma; myeloperoxidase; cardiovascular diseases; HDL; peroxidases; airway remodeling; intestinal microbiota; gut flora; cardiometabolic disease |
| Vincent Hascall, PhD | Hyaluronan in inflammation; asthma; diabetes; autophagy; hyperglycemia; connective tissue biology |
| Christopher Hine | Dietary restriction; aging; lifespan extension; stress resistance; exercise; hydrogen sulfide (H2S) production and metabolism; sulfur amino acid metabolism; endocrine signaling and longevity |
| Sadashiva Karnik, PhD | GPCRs; angiotensin receptors; ARBs; biased signaling; cardiac hypertrophy; hypertension; heart failure; structure-function of GPCRs; transmembrane signaling; microRNA; gene expression; chromatin protein modifications; STAT3 and U-STAT3 signaling; RGS proteins |
| Xiaoxia Li, PhD | Signal transduction in innate and adaptive immunity |
| Daniel Lindner, MD, PhD | Translational hematology and oncology research |
| Thomas McIntyre, PhD | Lipid mediators; inflammatory signaling; platelet biology; biochemistry; acute kidney injury |
| Richard Padgett, PhD | Transcription; RNA processing; RNA splicing; splicing factors; relation to cancer and developmental diseases; gene structure and function; genomics; evolution of genomes; RNA biochemistry |
| Edward Plow, PhD | Integrins; plasminogen; kindlins; thrombospondins; atherothrombosis |
| Eugene Podrez, MD, PhD | Atherosclerosis; thrombosis; atherothrombosis; platelets; macrophage; scavenger receptors; LDL; HDL; cholesterol; phospholipids; oxidative stress; lipid peroxidation. |
| Jun Qin, PhD | Signal transduction; integrin; cell adhesion; cell migration; kinase; heart disease; cancer; structural biology; protein NMR; protein crystallography |
| Sujata Rao, PhD | Eye; developmental biology; circadian clock; neurovascular development; thyroid hormone signaling; cone photoreceptors; vascular remodeling |
| Nima Sharifi, MD | Prostate cancer; androgens; metabolism; steroids; castration-resistant prostate cancer; androgen receptor; hormone therapy; medical oncology; dihydrotestosterone; enzymes; biochemistry |
| Robert Silverman, PhD | Interferon; rnase l; antiviral innate immunity; oncolytic virotherapy, DNA methyltransferase inhibitor |
| Jonathan Smith, PhD | Atherosclerosis; HDL metabolism; atrial fibrillation; genetics; genomics; eQTL; gene expression; reverse cholesterol transport; dysfunctional HDL; RNAseq; allelic expression imbalance; ABCA1; mouse models; zinc finger nuclease |
| George Stark, PhD | Interferons; IL-6; NFkB; STAT3; EGFR; drug resistance; DNA repair; lung cancer; breast cancer; prostate cancer; glioblastoma; septic shock |
| Dennis Stuehr, PhD | Inflammation; nitric oxide; heme transport; soluble guanylate cyclase; electron transfer |
| Wai Hong Wilson Tang, MD | Heart failure; cardiomyopathy; nitrative stress; metabolomics; cardio-renal syndrome |
| Bruce Trapp, PhD | Multiple sclerosis; glia; oligodendrocytes; astrocytes; neuroprotection; myelin, autism |
| Qing Wang, PhD | Cardiac arrhythmias and sudden death (VT, VF, AF); coronary artery disease (CAD) and myocardial infarction (MI); pulmonary arterial hypertension (PAH); vascular biology; genetics; genome-wide association studies (GWAS); next generation sequencing; genome editing; gene therapy |
| Qingyu Wu, MD, PhD | Blood pressure; cardiac function; cardiovascular disease; cell membrane proteases; corin; hormone processing; hypertension; preeclampsia; pregnancy-induced hypertension; proteolytic enzymes; vascular biology |
| Bin Zhang, PhD | Mechanism of intracellular trafficking in human disease development; protein secretion; endoplasmic reticulum stress; hemophilia; alpha-1-antitrypsin deficiency, cardiovascular diseases; cancer |
| Case Western Reserve University | |
| Romani Andrea MD, PhD | Regulation of magnesium homeostasis and transport in mammalian cells |
| Ge Jin, PhD | Mechanism of cancer cell-derived cytokines and/or metabolites; immune response and role of HIV-infection in development/progression of non-AIDS-defining cancers |
| Jeffrey Schelling, MD | Mechanisms of chronic kidney disease progression; in vitro molecular and cellular methods, animal models and human studies investigating glomerular and tubulointerstitial pathophysiology |
| Bing-Cheng Wang, PhD | Roles of Eph receptor tyrosine kinases in invasive growth and distal metastasis of cancer cells |
| Wen-Quan Zou, MD, PhD | Protein aggregation in the conformational diseases; pathologic prion proteins (PrPC and PrPSc) in prion diseases (PrD); neurotoxic amyloid β (Aβ) in Alzheimer disease (AD); Creutzfeldt-Jakob disease (CJD) |
Program Listing
Level(s) of training: PhD
Number of positions available per year: varies
Duration of program: 4-6 years
Approximate annual stipend: $21,000 (pre-candidacy assistantship); $22,500 (post-candidacy assistantship); Assistantship also provides full annual tuition fees.
Source of funding: Cleveland State University (teaching assitantships); Grant funding (research assistantships)
Current number of trainees: 13
Number of past graduates (over last 10 years): 36
Application Procedures
Prerequisites
Students must meet the requirements of the College of Graduate Studies and Department of Chemistry for admission to the chemistry graduate program. Minimum requirements for admission are bachelor’s degree in a basic science, laboratory medical science or related field, with a minimum grade point average (GPA) of 3.00. The requirement for obtaining and maintaining a teaching assistantship is a GPA ≥ 3.25, while the requirement for obtaining and maintaining a research assistantship funded by a grant is a GPA ≥ 3.00. Assistantships under normal circumstances are provided for up to 6 years of study in the program, contingent on above GPA requirements, as well as acceptable performance of duties. One year of general, organic, analytical, and physical chemistry; a year of physics; and mathematics through partial derivatives and multiple integrals is required. Applicants lacking any of these course requirements may be admitted, but any deficiency must be made up as soon as possible.
Procedures
Apply to the doctoral program in Clinical Bioanalytical Chemistry (in which the doctoral Clinical Chemistry program resides). Instructions, procedures and how to submit the application are given at:
United States applicants:
http://www.csuohio.edu/graduate-admissions/how-apply
International Applicants:
https://www.csuohio.edu/international-admissions/international-admissions-graduate-students-apply-admission
Materials required for application are official transcripts from undergraduate and graduate institutions attended and two letters of reference. Typically, chemistry applicants are required to submit an official report of their performance on the Graduate Record Examination (GRE) (verbal and quantitative) to the University by the Educational Testing Service (ETS). However, applicants with outstanding records (grade-point average above 3.0 in addition to other evidence of solid preparation) may request that this requirement be waived by the Graduate Committee of the Chemistry Department. The GRE requirement cannot be waived for international students. International students who do not have a degree from an institution in the United States must also arrange to have the results of their performance on the TOEFL [or other test/ways to demonstrate English proficiency (https://www.csuohio.edu/international-admissions/graduate-admission-requirements)] sent to the University.
Deadline
January 15 for admittance and assistantship awarding for Fall semester of the same year.
Program Description
The ComACC-accredited doctoral program in Clinical Chemistry is a dynamically integrated program merging the fields of biomedicine, clinical diagnosis, and analytical chemistry. The mission of the CSU-CC doctoral program in Clinical Chemistry is to give Ph.D. graduate students intensive didactic instruction in the field of clinical laboratory science, as well as some limited experience in the clinical laboratory, and finally to give significant biomedical research experience in dissertation work, in order to prepare students for one of the following paths upon graduation:
- to obtain further practical training in the field through clinical chemistry post-doctoral fellowships, in order to prepare them for careers as directors of clinical laboratories;
- to directly assume other scientific positions in clinical laboratories, either at medical institutions or reference laboratories;
- to assume positions in the in-vitro diagnostics, pharmaceutical or biotechnology industries, which are increasingly seeking scientists with knowledge of clinical chemistry.
The program sets high standards of excellence in delivering its curriculum to prepare students for these careers. Knowledge of both clinical aspects and interpretation of test results, as well knowledge of analytical techniques and various aspects of the quality operation in the clinical laboratory, are central to the program’s goals and mission. Additionally the program mentors students to become independent researchers, educating and mentoring the student in cutting-edge analytical methodologies and novel clinical/biomedical research, such that the Ph.D. recipient can make significant scientific contributions to the field of clinical chemistry. A particular analytical strength of the program is the dissertation research utilizing mass spectrometry instrumentation at CSU and the Cleveland Clinic. Finally the program involves students in the activities of the NEOhio American Association for Clinical Chemistry, fostering their professional development.
The doctoral degree program in Clinical Bioanalytical Chemistry, in which the ComACC-accredited program is a specialized tract, is a joint program of Cleveland State University and the Cleveland Clinic. The ComACC-accredited program is also affiliated with Children’s Hospital Medical Center of Akron, MetroHealth Medical Center, Saint Vincent Charity Medical Center, and University Hospitals Case Medical Center. The Clinical Chemistry program gives rigorous instruction in all aspects of disease processes, with in-depth coverage given for testing strategies and methodologies used in disease diagnosis. The instructional and training components are carried out by clinical chemistry faculty in the Department of Chemistry at Cleveland State University, with active participation of the clinical scientists at Cleveland area medical institutions and reference laboratories.
Doctoral clinical chemistry students take one year of Clinical Chemistry (two 4-credit courses); one year of Advanced Biochemistry (two 4-credit courses); a course in Biotechnology Techniques (4 credits), which is a laboratory course in traditional biomedical research techniques, or alternatively, a course in Pharmaceutical Analysis Laboratory (3 semester credits), which is a laboratory course in advanced analytical instrumentation techniques; a course in Clinical Laboratory Topics: Instrumentation and Quality Operation (4 credits), four Special Topics in Clinical Chemistry courses, covering various topics in clinical laboratory science (1 credit each), two or more Clinical Chemistry Seminar courses given at the Cleveland Clinic (1 semester credit each) and an Internship in Clinical Chemistry (3 credits) course, involving rotation in a medical center clinical laboratory, where the student learns the principles and practice of clinical laboratory testing. Students may also have the opportunity to work on developmental projects in clinical laboratory.
Dissertation research is an important component of the Clinical Chemistry PhD program. PhD students begin earnest work on their dissertation research at the start of their second year. Students do research at state-of-the-art facilities at Cleveland State University and the Cleveland Clinic. The program includes 64 faculty members who collectively have a broad range of research interests in the fields of disease mechanisms and diagnosis, bioanalytical chemistry, biomedicine, and molecular biology. CSU chemistry faculty undertake biomedical research in areas pertinent to clinical chemistry, including: mass spectrometry, HPLC, biomedical imaging, biosensors, nanotechnology, computational chemistry, coagulation biochemistry, protein chemistry, microarrays, molecular biology, cancer biochemistry, metabolomics, proteomics and pharmacokinetics. Program faculty at the Lerner Research Institute at Cleveland Clinic undertakes basic biomedical research in the areas of molecular biology, cellular and molecular medicine, cancer biology, neurosciences, molecular cardiology, immunology, pathobiology, genomic medicine, stem cell biology and regenerative medicine, ophthalmic research and biomedical engineering.